The tires are Kenda 761 which are tube type. I initially used an RV alkyd roof coating to seal the spokes because it stands heat, weather and is very chemical resistant. It retains some flexibility when cured "hard" and is very tough to scrape or shear from the surface.
Two potential issues were encountered:
1) I could not discover whether this material is glycol tolerant and since the sealers such as Slime are glycol based, I removed the sealer when a sealing fault was discovered. I did not use Slime with this sealer because I wished to achieve a reliable sealer without one of the liquid sealers. The fault was a leak at one spoke due to not having sufficient adhesion when applying the alkyd sealer. I cleaned the rim and spokes more thoroughly before applying the second sealer type. I had initially determined to do only a cursory cleaning in order to discover whether a seal could be achieved without being anal but apparently not. This was a bit of a surprise because the alkyd sealer seems willing to jump ten feet to stick to a good pair of pants.
2) On removing the tire, I recognized that the alkyd had not cured up in the manner generally experienced on RV exterior surfaces so concluded that I should have heat cured with a hot air gun. If I determine that this sealer will tolerate glycols, and decide to seal another set of wheels, I may try that technique.
There was initially some problem with leakage around the beads but after running the wheel bead area onto my bench grinder's wire wheel and applying tire rim grease, all has been well for several thousand miles.
The second sealing attempt was to wire wheel buff, then use a commercial adhesive remover, followed by brake and parts cleaner. I detailed any suspect areas with razor scraper and scotch brite pad by hand.
Some friends have used Permatex silicone gasket maker but since this is not fuel tolerant and has lower adhesion and tensile strength, I decided to use an automotive body seam sealer. I don't thing anything dissolves that stuff.
The sealer is Pro Form PF244 which is a urethane sealer in a calking gun tube because that's easier to apply and poke into reluctant areas than "toothpaste tubes". I didn't check to see if is available in other than calking tubes so may not be.
This sealer has been very good excepting when I attempted adjustment of one spoke and broke the seal on that spoke. I pulled both the front tire (now leaking) and rear to apply a heavier layer.
The tires don't seem to require adding air more often than tube type, FWIW. I've been waiting for the front to wear down further before poking some holes to apply plugs. Having installed thousands of tubeless tire plugs, it's hard to imagine how there will be any new wrinkles excepting perhaps if I run Slime in the tires. Presently I have Slime in the rear only as didn't have enough to do both last time I had the tires off.
Slime is easy to wash off, using garden hose and a soft brush so not a problem. I have not used tire plugs in conjunction with Slime so want to do some experiments.
If I do more tires, I will experiment with applying some grease or other means of preventing the sealer adhering to the spoke. Not certain that it is a big deal but would be a nice touch rather than to reseal.
The weight reduction from both tires is significant which was a not considered benefit since my intention was only to be able to use tire plugs rather than to remove a tube to repair.
If I've left something out or forgotten to consider some aspect, I'd be happy to respond.
I agree with Fireground -- please post more.
I also searched your posts and didn't find which system you used -- there are people using Goop, silicone, tape, and others.
Which sealing method did you use and what tires so far?