To the best of my knowledge, the ProCycle 180F thermostat is the same OD as the stock oem KLR 160F thermostat.
But unless you are riding the Sahara Desert ALL the Time, I wouldn't suggest it.
Remember that the designer of the Thermo-Bob lives in Scottsdale, AZ. And his bike has over 160,000 miles on it with the Thermo-Bob 195F thermostat.
Doubtless (or at least, little doubt) this aspect has been discussed before (don't remember content or context); what is good, bad, and/or ugly about . . . installing a higher-temperature-than-stock thermostat (180 degrees, 195 degrees) in an otherwise STOCK KLR???????????
In the bad old days, when there was ice and snow (and maybe a, "Ho! Ho! Ho!"), folks installed "WINTER" thermostats, replacing the stock thermostats in the liquid-cooled internal combustion engines powering their vehicles. (Consideration may be irrelevant, since in a few years we won't have any internal combustion engines whatsoever (and no cows, either).)
If such a measure were taken on a KLR, would the act comprise ENGINE ABUSE? If so, HOW? The heartbreak of, "thermal shock?"
("Inquiring minds want to know!")