I took my Dell to Kenya a few months ago, and it tolerated a few hours in a Land Cruiser and being toted around in a backpack very well. But if you subject it to continual vibration, you can count on it dieing. If you really want to take your laptop with you, you should invest in a Panasonic Tough Book. They're about twice the cost of a nice laptop, but they are designed to take virtually anything you can dish out, including rain, vibration, heat, cold, being dropped, etc. It's that or do without a laptop.
I suppose you could look into a very well padded Pelican case, and hope for the best, but I'm afraid you'll be disappointed.